Job Description

Sussex Research Laboratories Inc.
100 Sussex Drive, Suite 1120B
Ottawa, Ontario, Canada K1A 0R6

Position: Glycoscientist

Terms of Employment: Full-time, Permanent, 35 hours per week

Language of Work: English

Wage: $42.50 per hour

Benefits Package: Dental and medical coverage available after a required 3-month probationary period.

Location of Work: Ottawa, Ontario

Position Summary:

Sussex Research Laboratories Inc. seeks an experienced Glycoscientist to lead the development, synthesis, and purification of glycan-based products. The ideal candidate will demonstrate expertise in glycan and organic synthetic chemistry, particularly glycosylation methods (chemical, enzymatic, and chemoenzymatic).

Key Responsibilities:

• Independently design, plan, and execute scalable glycan production.
• Conduct multi-step synthesis of carbohydrate-based compounds, including glycoamino acids, glycopeptides, oligosaccharides, glycolipids, and glycoconjugates.
• Utilize column chromatographic techniques (HPLC) for isolation, purification, and identification of synthetic targets.
• Analyze data using advanced NMR and mass spectrometry techniques.
• Perform chemical and enzymatic conjugations to carrier proteins.
• Keep and maintain experimental development records and write final technical reports on completion of projects.

Mandatory Skills and Expertise:

• Extensive experience (Ph.D. combined with relevant postdoctoral and/or industrial experience) in carbohydrate synthetic chemistry.
• Expertise in glycosylation, protection, and deprotection strategies.
• Expertise in synthesis of mycobacterial peptidoglycans and their probes.
• Expertise in chemical synthesis of glycophosphates as natural enzyme substrates.
• Expertise in chemical synthesis of GlcNAc-PP-lipids and lipid-pyrophosphates.
• Proficiency in analytical tools (e.g., HPLC, LC-MS, NMR).
• Proficiency in bioanalytical assays relating to glyco- and bioconjugation (e.g. gel electrophoresis, colourimetric and fluorescence assays)
• Ability to meet tight deadlines in a dynamic R&D laboratory.
• Alignment with Sussex Research Core Values: Dedication, Innovation, Communication, Excellence, Respect, Integrity, and Accountability.

Education and Experience Requirements:

• Ph.D. in glycoscience with emphasis on carbohydrate synthesis and characterization.
• At least 3 years of post-graduate experience in glycoscience within academia or industry.

How to Apply:
Submit your CV, a description of relevant projects, and a cover letter to admin@sussex-research.com.